The Clinical Effect of Sugammadex Sodium (Domestic) for Antagonizing Neuromuscular Blockade After Thoracic Surgery

Launched by THE FOURTH AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE · Mar 27, 2024

Keywords

ClinConnect Summary

This clinical trial is studying two medications, sugammadex and neostigmine, to see which one is better at reversing muscle relaxation after lung surgery. When patients have surgery, they often receive muscle relaxants to help with anesthesia, but these need to be reversed afterward so patients can breathe normally again. The goal of the trial is to find out if sugammadex (a domestic version) works more effectively than neostigmine for this purpose.

To participate in this trial, patients must be 18 years or older, undergoing elective lung surgery that requires general anesthesia and a breathing tube, and will be given a muscle relaxant called rocuronium. Certain patients will not be eligible, such as those with specific allergies, severe health issues, or any factors that might complicate the surgery or recovery. If you join the trial, you can expect to receive either sugammadex or neostigmine after your surgery, and the results will help improve how muscle relaxants are managed in the future.

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Eligibility criteria

• Inclusion Criteria:
• • 1. Patients who undergo elective lung surgery under general anesthesia and require endotracheal intubation;
• • 2. Age\>18 years old, gender not limited;
• • 3. American Society of Anesthesiologists ASA Level I-III;
• • 4. Use rocuronium bromide for neuromuscular blockade;
• • 5. The patient voluntarily participated in the trial.
• Exclusion Criteria:
• • 1. The patient explicitly refused to participate in this trial;
• • 2. Family history of malignant hyperthermia, patients with allergies to sodium sulbactam, neostigmine ingredients and their excipients, and patients with allergies to drugs used during general anesthesia;
• • 3. Patients with tracheal malformations or suspected difficult airways, coagulation dysfunction, severe liver and kidney dysfunction, and severe lung disease;
• • 4. Patients who are not extubated and sent to the ward or ICU after surgery;
• • 5. The researchers believe that patients with any other unfavorable factors to participate in this trial.