Impact of Sodium Bicarbonate on 24-hour Urine Parameters in Hypocitriuric and Uric Acid Stone Formers

Launched by UNIVERSITY OF CALIFORNIA, IRVINE · Mar 21, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of sodium bicarbonate, commonly known as baking soda, on patients with uric acid kidney stones. The goal is to see if taking baking soda can help increase certain substances in the urine that may prevent the formation of kidney stones. Currently, many patients use a medication called Urocit-K to help with this, but it can be expensive and may have side effects. Researchers believe that baking soda could be a cheaper and effective alternative.

To participate in the trial, individuals need to be between 18 and 80 years old and have low levels of citrate in their urine. They should also be current users of Urocit-K for their kidney stones. Participants will take baking soda twice a day mixed with a liquid, like water or juice. This study is not yet recruiting, but it aims to offer a more affordable and accessible way to manage kidney stone risk for those who qualify.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • \> 18 years of age and \< 80 years of age,
• • Hypocitriuric (\<320 mg/24 hours), Calcium Oxalate Stone or Uric Acid stone formers, currently on Urocit-K therapy as the standard of care.
• Exclusion Criteria:
• • Male or female \<18 years old or \> 80 years old.
• • Currently taking thiazides or ACE inhibitor medications
• • Pregnant women.
• • Women who are breastfeeding or plan to breastfeed during study period
• • History of abnormal renal function (defined as eGFR \<60 mL/min/1.73 m2), active urinary tract infection, diabetes, cystinuria, renal tubular acidosis, inflammatory bowel disease, chronic diarrhea, primary hyperparathyroidism, peptic ulcer disease.