Metabolic Flexibility and Autonomic Control After Muscle Power vs Metabolic Power Training in Postmenopausal Oncological Women: the POWER Health Study

Launched by UNIVERSITY OF VALENCIA · Mar 27, 2024

Keywords

ClinConnect Summary

The POWER Health Study is a clinical trial designed to understand how different types of exercise can affect heart health and metabolism in postmenopausal women who have had breast cancer. The study will compare two types of exercise over eight weeks: high-intensity interval training (HIIT) and strength training focused on building muscle power. The goal is to see how these exercises can improve cardiovascular health and the body's ability to use energy effectively.

To be eligible for this study, participants should be women aged 35 to 75 who have been diagnosed with breast cancer but are currently cancer-free or have not had cancer in the last 15 years. They should not have been physically active in the last three months and should be willing to provide consent for participation. If you join the study, you can expect to participate in supervised exercise sessions and contribute to important research that may help improve health outcomes for women in similar situations. It's important to know that if you have certain medical conditions or are taking specific medications, you may not be able to participate.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Patients diagnosed of relapse free-cancer (RFC) or patients not diagnosed of any cancer at least the last 15 years (CG)
• • Aged between 35 and 75 years
• • Diagnostic of breast cancer (i.e., including ductal carcinoma, invasive carcinoma, triple negative; RFC) or physiological menopause (CG)
• • Not participating in a nutritional/dietary intervention
• • Not being physically active (i.e., not to be participating in any physical exercise program in the last 3 months, or performing less than 600 metabolic equivalents (METS)/week of moderate-vigorous physical activity).
• • To be capable and willing to provide informed consent
• • Not to suffer from any specific condition that may impede testing of the study hypothesis or make it unsafe to engage in the exercise intervention (i.e., determined by the research staff).
• Exclusion Criteria:
• • Medical contraindication for being engaged in an exercise.
• • Additional surgery planned within the intervention
• • Consuming usually betablocker or any drugs alterning nervous system functioning
• • History of another primary invasive cancer (RFC) or suffer a serious chronic illness (CG)
• • To present any of the following cardiac conditions: (i) myocardial infarction or coronary revascularization procedure within prior 3 months, (ii) uncontrolled hypertension (i.e., systolic ≥180 mmHg or diastolic ≥100 mmHg), (iii) uncontrolled arrhythmias (iv) valvular disease clinically significant, (v) decompensated heart failure or (vi) to suffer from known aortic aneurysm.