Role of Mucosal Impedance Measurement for the Diagnosis of Gastroesophageal Reflux Disease

Launched by HOSPITAL DE CLINICAS JOSÉ DE SAN MARTÍN · Mar 27, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new method to help diagnose gastroesophageal reflux disease (GERD) more accurately using a technology called mucosal impedance measurement. This device can assess changes in the esophagus related to chronic reflux, potentially improving the diagnosis for patients who have symptoms of GERD but show normal results during standard tests. The goal is to see how well this new device works compared to existing methods, especially in patients who haven’t responded well to typical treatments like proton pump inhibitors.

To participate in this trial, individuals must be over 18 years old and have symptoms of GERD that haven’t improved after at least 8 weeks of treatment. They should also have had an upper endoscopy that didn’t show any signs of damage to the esophagus. Participants will undergo a screening period and then have the mucosal impedance measurement along with other standard tests during an endoscopy. It’s important to note that certain conditions, such as pregnancy or specific esophageal disorders, may exclude someone from joining the study. This trial is being conducted at a hospital in Buenos Aires, Argentina, and aims to provide better diagnostic tools for GERD.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients \>18 years presenting symptoms of GERD that have not adequately responded to proton pump inhibitors (PPIs) treatment after 8 weeks and have undergone upper gastrointestinal endoscopy (UGIE) without erosive esophagitis.
• • Patients with a broad spectrum of severity, assessed through the GERDq score, will be included
• Exclusion Criteria:
• • ● Pregnancy or lactation
• • Esophageal disorders (esophageal motor disorders, eosinophilic esophagitis, neoplastic diseases)
• • Uncontrolled systemic diseases (diabetes mellitus, hypo- or hyperthyroidism, cancer, etc.)
• • Lack of informed consent
• • Severe psychiatric disorders