Impact of Metabolic Flexibility on Changes in Metabolic Health
Launched by PENNINGTON BIOMEDICAL RESEARCH CENTER · Mar 25, 2024
Trial Information
Current as of August 20, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
Metabolic flexibility is the capacity to adapt fuel oxidation to fuel availability so that ATP synthesis can match its cellular demands. Thus, for example, increases in glucose availability after a meal would increase glucose oxidation, while increases in lipid availability during fasting would increase lipid oxidation. Enhanced metabolic flexibility has been proposed to protect humans from ectopic lipid accumulation and the subsequent development of insulin resistance and metabolic syndrome.
In humans, metabolic flexibility is assessed by measuring relative macronutrient oxidation (i.e., ...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Individuals who participated in the InSight study at Pennington Biomedical in 2008-2009.
- Exclusion Criteria:
- • Women who are currently pregnant or breastfeeding, have been pregnant in the last 12 months, and/or were breastfeeding in the last 6 months.
About Pennington Biomedical Research Center
The Pennington Biomedical Research Center, part of Louisiana State University, is a leading institution dedicated to advancing the understanding of nutrition, physical activity, and chronic disease prevention through innovative research. With a focus on obesity, metabolic disorders, and related health outcomes, the center conducts rigorous clinical trials and translational studies aimed at improving public health. Its multidisciplinary team of scientists and clinicians collaborates to translate research findings into practical applications, fostering healthier lifestyles and informing policy. Committed to excellence in research and education, the Pennington Biomedical Research Center plays a pivotal role in shaping the future of health and wellness.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Baton Rouge, Louisiana, United States
Patients applied
Trial Officials
Rodrigo Fernández-Verdejo, PhD
Principal Investigator
Pennington Biomedical Research Center
Eric Ravussin, PhD
Principal Investigator
Pennington Biomedical Research Center
Leanne Redman, PhD
Principal Investigator
Pennington Biomedical Research Center
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported