The Application of Contrast-enhanced Ultrasound in Acute Kidney Injury in ICU

Launched by PEKING UNIVERSITY THIRD HOSPITAL · Apr 1, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a special type of ultrasound called contrast-enhanced ultrasound to understand changes in blood flow to the kidneys in patients with acute kidney injury (AKI) while they are in the intensive care unit (ICU). The researchers want to see how these changes in kidney blood flow relate to overall blood circulation and whether they can predict how well the kidneys will recover. This information could help doctors make better decisions about treatment for patients with serious kidney problems.

To participate in the study, patients need to be at least 18 years old and diagnosed with AKI within 24 hours of being admitted to the ICU. They should expect to stay in the ICU for at least 48 hours. The ultrasound will be performed within 24 hours of their AKI diagnosis. However, patients with severe chronic kidney disease, those on dialysis, or certain other health conditions may not be eligible. If you or a loved one is considering participation, the study aims to provide valuable insights that could improve care for kidney injuries in critically ill patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age \>18 years old;
• • AKI was diagnosed \< 24 hours after first admission to intensive care unit (ICU) and the expected length of stay in ICU ≥48 hours;
• • Meet Kidney Disease Improving Global Outcomes (KDIGO) 2012 diagnostic criteria for acute kidney injury;
• • Contrast-enhanced ultrasound was performed within 24 hours after diagnosis of acute kidney injury (AKI).
• Exclusion Criteria:
• • Known severe chronic kidney disease (CKD≥ stage 4) or undergoing hemodialysis treatment;
• • Kidney transplantation or renal malignancy;
• • Terminal stage of malignant tumor;
• • Pregnancy;
• • Renal artery stenosis or renal vein thrombosis;
• • Allergy to contrast agent SonoVue(BraccoSpA, Milan, Italy) or its components, or the presence of severe cardiopulmonary insufficiency (e.g., right-to-left shunt heart disease or pulmonary systolic blood pressure \>90mmHg).