Gait and Balance Impairment in Rare and Very Rare Neurological Diseases

Launched by ISTITUTO AUXOLOGICO ITALIANO · Mar 26, 2024

Keywords

ClinConnect Summary

This clinical trial, called MaNeNeND, is focused on understanding how balance and walking abilities are affected in individuals with rare and very rare neurological diseases, as well as those with undiagnosed conditions. These diseases can impact the nervous system and may lead to problems with movement and an increased risk of falls, which can result in serious injuries. The study aims to gather important information about how these conditions progress and how they can be diagnosed and treated more effectively.

To be eligible for the trial, participants must be over 18 years old and have a specific neurological condition like multiple sclerosis, Parkinson's disease, or a rare neurological disease. They should also be able to stand and walk independently for a short distance. Participants will complete several assessments, including questionnaires about their balance and fatigue, as well as physical tests to measure their walking speed and balance. This research will help to better identify the unique challenges faced by those with these rare conditions and will contribute valuable data for future studies.

Gender

ALL

Eligibility criteria

• • Inclusion criteria
• • Multiple sclerosis, Parkinson's disease, peripheral neuropathy of the lower limbs or rare or ultrarare neurological disease (e.g. la Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome - CANVAS, ORPHAcode: 504476; Wilson's disease, ORPHAcode: 905)
• • undiagnosed neurological disease, i.e. a neurological disease that remains unknown after a full diagnostic assessment;
• • age \> 18 years;
• • ability to stand upright with no assistance and no assistive device for \> 30 seconds;
• • ability to walk without assistance and with no assistive device for \> 50 m;
• • ability to give their informed consent.
• • Exclusion criteria
• • pregnancy or breastfeeding
• • any other medical conditions affecting by itself balance and gait (e.g. lower limb amputation, hemiparesis due to a stroke)
• • major orthopaedic surgery (e.g. hip or knee replacement).