Valacyclovir Monotherapy in Pain Management of Acute Periapical Abscesses After Emergency Chamber Opening

Launched by DOW UNIVERSITY OF HEALTH SCIENCES · Mar 27, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how well a medication called valacyclovir works to help reduce pain after a dental procedure for a condition known as an acute apical abscess, which is an infection at the tip of a tooth root. In the study, 82 adults will be divided into two groups: one group will receive valacyclovir, and the other group will receive a standard pain treatment called naproxen sodium. Researchers will measure pain levels over six days using a simple scale where patients rate their pain from 0 (no pain) to 10 (worst pain imaginable).

To participate in the trial, patients need to be at least 18 years old and in good health, showing signs of tooth infection with moderate to severe pain. Unfortunately, people who are currently taking antibiotics or antivirals, smokers, pregnant or nursing mothers, or those allergic to valacyclovir cannot join. If you are eligible and decide to participate, you'll be helping to find out if valacyclovir can be an effective pain management option for this type of dental issue.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient Age ≥18 years old
• • Healthy patient American Society of Anesthesiologists (ASA) class l and ll.
• • Patients having clinical evidence of pulp necrosis and acute apical abscess with radiographic signs of periapical disease.
• * Main inclusion criteria is that patient should have moderate to severe pain, it can be calculated as:
• • 1 to 3 as Mild pain. 4 to 6 as moderate pain. 7 to 10 as severe pain.
• Exclusion Criteria:
• • Patient currently on antibiotics or antivirals
• • Smokers
• • Unusual tooth anatomy or inaccurate diagnosis
• • Pregnant or nursing mothers
• • Patients allergic to valacyclovir