Low-dose Arginine-vasopressin Supplementation on Post-transplant Acute Kidney Injury After Liver Transplantation (AVENIR Trial)

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Mar 27, 2024

Keywords

ClinConnect Summary

The AVENIR Trial is studying whether a treatment called low-dose arginine-vasopressin can help reduce the risk of acute kidney injury (AKI) in patients after they undergo a liver transplant. AKI is a common complication after this surgery, and it can lead to long-term kidney problems. The researchers believe that arginine-vasopressin, a hormone that helps regulate blood pressure, might protect the kidneys during and after the transplant process.

To participate in this trial, you need to be an adult (18 years or older) scheduled for a liver transplant and able to provide informed consent. However, if you are in a medical emergency situation, have severe kidney disease, or are pregnant or breastfeeding, you won't be eligible. Participants will receive clear information about the study and will be closely monitored throughout the process. This trial is not yet recruiting participants, but it aims to find a safer way to manage kidney health after liver transplants, which could lead to better overall outcomes for patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years
• • Any adult patient with a scheduled liver transplantation
• • All participants will need to be given clear information about the study and give signed informed consent.
• • Person affiliated to the Social Security
• Exclusion Criteria:
• • Super-emergency for liver transplantation or fulminant hepatitis
• • Patient listed for or receiving simultaneous liver-kidney transplantation (SLKT)
• • Patients with end-stage renal disease (chronic eGFR \< 15 mL/min/1.73 m2 or requiring extra-renal purification before liver transplantation
• • Patient with epilepsy
• • Hypersensitivity to arginine-vasopressin and to its excipients
• • Patient refusal
• • Patients for whom it is impossible to give informed consent (language barrier)
• • Adults under guardianship or trusteeship, persons deprived of their liberty
• • Patient enrolled in another interventional clinical study
• • Pregnancy or breastfeeding