NRM on Vascular Perfusion in Healthy Adults

Launched by MAYO CLINIC · Mar 28, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how a dietary supplement called nicotinamide riboside might affect heart and blood vessel health in healthy adults. Researchers want to see if this supplement can improve something known as vascular stiffness, which relates to how flexible our blood vessels are. The study is currently recruiting participants who are between 40 and 60 years old and are in good health overall.

To take part in this study, you need to be able to give your consent, not be pregnant, and agree to follow the study rules. Additionally, you should not have certain health conditions, like high blood pressure that requires medication or any serious chronic illnesses. If you join the study, you can expect to follow specific procedures and possibly take the supplement for a set period. Remember, this is an opportunity to contribute to research that could help improve cardiovascular health!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • \>= 40 and \<=60
• • Provides consent to participate in the study
• • Not pregnant at time of consent
• • Understands and agrees to follow all study procedures and limitations
• • Have no contraindicating comorbid health condition as determined by the clinical investigators
• Exclusion Criteria:
• • Pregnant, nursing, or trying to conceive
• • BMI Restrictions: \<30
• • Allergy or sensitivity to study agent ingredients
• • Hypertension treated with medication
• • Use of natural health products containing nicotinamide riboside, quercetin, trans-resveratrol, or betaine anhydrous within 7 days prior to randomization and during the course of the study.
• • Surgery planned during the course of the trial
• • History or past diagnosis of chronic diseases, unstable medical conditions, blood/bleeding disorders or stroke
• • History or current diagnosis of cancer (except for successfully treated basal cell carcinoma diagnosed less than 5 years prior to screening or cancer in full remission more than 5 years after diagnosis.
• • Abnormal blood chemistries for renal or liver function (defined as 1 standard deviation outside of the normal range), alcohol dependence, uncontrolled thyroid disease, severe obesity (body mass index \>40 kg m-2), or weight stable for at least 3 months prior to enrolling in the study (defined as \>2 kg change in body mass).
• • An unstable medical or mental health condition as determined by the physician investigator.