Paracetamol-Tramadol and Paracetamol-caffeine Versus Placebo in the Emergency Discharge Treatment of Renal Colic

Launched by UNIVERSITY OF MONASTIR · Apr 1, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring the effectiveness of two different pain relief combinations—paracetamol with tramadol and paracetamol with caffeine—compared to a placebo (a treatment that has no active ingredients) for patients being discharged after experiencing renal colic, which is severe pain caused by kidney stones. The goal is to see which treatment best helps manage pain once patients leave the hospital.

To participate in this study, individuals must be over 18 years old, have experienced sudden flank or lower back pain that has been diagnosed as renal colic, and have a pain score of less than 30 when they are discharged. Pregnant or breastfeeding women, as well as those with certain kidney conditions, cannot participate. If eligible, participants will be randomly assigned to one of the three groups and will receive their assigned treatment upon leaving the emergency department. This trial is currently recruiting participants and aims to improve pain management options for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • -Age \> 18 years old.
• • Consent to participate in the study.
• • Pain in the flank/lumbar fossa of sudden onset with urine strips and/or imaging corresponding to the diagnosis of renal colic.
• • Pain score at discharge \< 30 (visual analog scale - VAS or verbal numerical scale - VAS from 0 to 100).
• Exclusion Criteria:
• • -Inability to appreciate pain according to the VAS.
• • Pregnant or breastfeeding woman.
• • Renal insufficiency with creatinine clearance \< 60 ml/min.