Impact of Grape Powder Consumption on Eye Health and Glycemic Status in Singapore Older Adults

Launched by NATIONAL UNIVERSITY OF SINGAPORE · Apr 4, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how consuming freeze-dried grape powder may affect eye health and certain substances in the blood that can be harmful, especially in older adults in Singapore. Researchers believe that eating this grape powder regularly could help improve vision and lower levels of these harmful substances compared to those who don't consume it.

To participate in this study, you need to be between 60 and 85 years old and able to speak and understand English. However, certain people can't join, like those who smoke, have serious eye diseases, or have specific health conditions like diabetes or heart disease. If you join, you'll be asked to take either the grape powder or a placebo (a harmless substitute that looks like the real thing) and monitor any changes in your eye health over time. This study could provide valuable information about how diet can influence eye health in older adults.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Male and female participants, aged between 60 and 85 years old inclusive
• • 2. English-literate and able to give informed consent in English
• Exclusion Criteria:
• • 1. Smokers
• • 2. Allergy to grapes or food dyes/additives, or had serious food allergies in the past
• • 3. Known eye diseases (macular degeneration, cataracts, retinopathy or glaucoma), blindness in at least one eye or have had eye surgery
• • 4. Unable to view bright lights or flashing lights
• • 5. Has Type 1 or 2 diabetes, uremia, cardiovascular disease, abnormal kidney and liver function
• • 6. Taking eye medication and/or dietary supplements for the eyes for the past 3 month
• • 7. Taking supplements containing carotenoids (e.g. Vitamin A, lutein, zeaxanthin) for past 3 months
• • 8. Currently on a specialised diet (e.g. vegetarian, vegan, weight loss diet, low fat diet
• • 9. Consumes more than 2 alcoholic drinks per day i.e. one drink is defined as either 150ml of wine,340ml of beer/cider or 45ml of distilled spirit
• • 10. Significant change in weight (≥ 3 kg body weight) in the past 3 months
• • 11. Significant exercise pattern over the past 3 months defined as high-intensity exercise of more than 3 hours per week
• • 12. Currently on anti-hypertensive, cholesterol-lowering or psychoactive drugs
• • 13. Scored ≤ 7 on the abbreviated mental test
• • 14. Poor peripheral venous access based on past experiences with blood draw
• • 15. Participating in another clinical study