Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury

Launched by UNIVERSITY OF COLORADO, DENVER · Apr 4, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a method called pulsatile flow during a procedure known as cardiopulmonary bypass, which is often used in heart surgeries. The goal is to see if using this pulsatile flow can help reduce the risk of acute kidney injury, a serious condition that can happen after surgery. Researchers will compare the results of patients using pulsatile flow with those using a steady, non-pulsatile flow to find out which is safer and leads to better outcomes.

To participate in this trial, patients should be between the ages of 65 and 74 and scheduled for elective (planned) heart surgery that involves cardiopulmonary bypass. However, those who are having emergency surgeries, heart or lung transplants, or certain other medical conditions would not be eligible. If you join the trial, you can expect to receive standard care for your surgery, with the added possibility of being part of this important research aimed at improving surgical outcomes. This trial is not yet recruiting participants, but it represents an opportunity to contribute to advancements in cardiac care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Able to provide informed consent
• • Scheduled for elective cardiac surgery with cardiopulmonary bypass
• • Exclusion Criteria
• • Emergency procedures
• • Scheduled for heart or lung transplantation
• • Scheduled for ventricular assist device implantation
• • Use of the Medtronic Elongated Once-Piece Arterial Cannula
• • Diagnosed with sepsis
• • Diagnosed with delirium
• • Experiencing hemodynamic instability (heart rate \> 100 and systolic blood pressure \< 90)
• • Requiring mechanical circulatory support
• • Requiring vasoactive medications