Evaluating Changes in Skeletal Muscle Proteins Following Resistance Exercise and Single-Leg Disuse

Launched by QUEEN'S UNIVERSITY · Apr 1, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how different factors, like exercise and nutrition, affect the size and health of skeletal muscles. Skeletal muscles are important for movement and overall health, and the researchers want to learn more about how they change in response to resistance training, a lack of activity, and the intake of essential amino acids—nutrients that help build muscle. By understanding these changes better, the researchers hope to find ways to help people maintain muscle mass as they age or when they are not able to exercise.

To participate in this trial, you need to be a healthy woman aged 18 to 30 with a body mass index (BMI) between 18 and 28. You should exercise at least two days a week and not have any serious medical conditions, like diabetes or cancer. Participants will go through assessments to ensure they are healthy and will be involved in exercises related to the study. It’s important to note that those who are currently pregnant or have certain health issues may not be eligible. This trial aims to provide valuable insights into keeping our muscles strong and healthy, especially during times of inactivity.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Females 18-30 years
• • BMI between 18-28 kg/m2
• • ≥2 days per week of structured exercise
• • Generally healthy as assessed by medical and physical activity questionnaires
• • Participants not currently pregnant
• Exclusion Criteria:
• • Any muscular, neurological, respiratory, or metabolic disease including diabetes
• • Any form of cancer currently or in the last 5 years
• • Bleeding disorders or antiplatelet / anticoagulation therapy
• • Currently taking fish oils or within the last 6 months
• • Currently taking any form of steroid or within the last 3 months
• • Inability to attain magnetic resonance imaging scans
• • Known irregular responses to physical activity (e.g., shortness of breath, chest pain, dizziness, etc.)
• • Any current illness
• • Currently smoking or smoking within the last 6 months
• • Currently pregnant
• • Any concurrent medical, psychiatric, or orthopedic condition that, subject to investigators' discernment, would negatively affect the subject's ability to comply with the study requirements