Efficacy and Safety of Angiotensin II Injection Versus Placebo in Patients With Refractory Distributed Shock

Launched by CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. · Apr 2, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating the use of angiotensin II, an injection that may help improve blood pressure in patients with a condition called refractory distributive shock. This is a serious condition where the body doesn’t get enough blood flow, even after receiving standard treatments. The study will compare the effects of angiotensin II to a placebo (a treatment that looks the same but has no active medication) to see if it can help more patients reach their target blood pressure. The trial will enroll 214 participants aged 18 to 75 years who are currently receiving certain medications for their shock but still have low blood pressure despite treatment.

Participants in this study can expect to receive either the angiotensin II injection or the placebo, and neither they nor the study staff will know which one they are getting until the study is completed. To be eligible, potential participants must have specific medical conditions and be stable enough to stay in the hospital for at least the first 48 hours of the study. It’s important for patients and their families to understand that this trial is focused on finding new ways to help those with severe blood pressure issues and that safety is a top priority.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age: 18 years to 75 years old, male or female;
• • diagnosis of distributive shock;
• • on the basis of the treatment of total vasoactive drugs dose \> 0.2 μg/kg/min norepinephrine (or equivalent dose of another vasoactive drug: such as epinephrine \> 0.2 μg/kg/min, dopamine \> 30 μg/kg/min, phenylephrine \> 2 μg/kg/min, vasopressin \> 0.08 U/min) and continuous treatment for at least 6 hours and no more than 48 hours, the patient's mean arterial pressure can still only be maintained between 55 and 70 mmHg, or do not reach the target MAP assessed by clinicians, it can be diagnosed as refractory distributive shock.
• • have central venous access and arterial catheters, and are expected to be present for at least the first 48 hours of the study.
• • indwelling catheter, and expected to be present for at least the first 48 hours of the study.
• • patient has received at least 30 mL/kg of crystalloid or colloid volume in the previous 24 hours or has undergone adequate volume resuscitation in the opinion of the investigator.
• • patients must have one of the following criteria with clinical features of high-output shock
• • 1. Central venous oxygen saturation (ScVO2) \> 70% (via saturation catheter or central venous blood gas) and central venous pressure (CVP) \> 8 mmHg.
• • 2. cardiac index (CI) \> 2.3 L/min/m2.
• • the patient or legal representative is willing and able to provide written informed consent and comply with all protocol requirements.
• Exclusion Criteria:
• • Patients with burns \> 20% of total body surface area;
• • Patients with cardiovascular (CV) SOFA score ≤ 3;
• • Patients with acute coronary syndrome requiring interventional therapy;
• • Patients treated with Extracorporeal Membrane Oxygenation (ECMO);
• • Patients with end-stage liver failure (Model for end-stage liver disease score (MELD) \> 30).
• • Patients with a diagnosis of asthma or bronchospasm.
• • Patients with a diagnosis of acute mesenteric ischemia, or patients with suspected acute mesenteric ischemia.
• • Patients with a history, presence, or high suspicion of aortic dissection or abdominal aortic aneurysm, or patients diagnosed with aortic dissection or abdominal aortic aneurysm.
• • Patients who have been diagnosed with malignant tumor within the past 2 years, except for early malignant tumors (carcinoma in situ or stage I tumor) that have been radically treated or expected to recover after treatment, such as adequately treated thyroid cancer, cervical carcinoma in situ, basal cell or squamous cell carcinoma.
• • Patients with Raynaud's phenomenon, systemic sclerosis or vasospastic disease.
• • Patients with life expectancy ≤ 24 hours as assessed by the study physician.
• • Patients with active bleeding who are expected to require transfusion of \> 4 units of packed red blood cells within 48 hours of study start.
• • Patients with active bleeding and hemoglobin \< 7 g/dL or any other condition that contraindicates serial blood sampling.
• • Patients with absolute neutrophil count (ANC) \< 1000 cells/mm3.
• • Patients with known hypersensitivity to angiotensin II injection and its excipients.
• • Patients who are currently participating in another interventional clinical trial.
• • Blood/urine pregnancy test should be performed for patients with known pregnancy at screening and those with clinical suspicion of pregnancy.
• • Patients who are considered unstable by the investigator or have any condition that would affect the safety of the study or the interpretation of the study results, or that would prevent the patient from completing the study, including but not limited to cardiovascular, gastrointestinal, hepatic, renal, neurological, musculoskeletal, infectious, endocrine, metabolic, hematological, psychiatric, or major physical disorders. For example: patients with arrhythmia, uncontrolled hyperglycemia, cerebrovascular disease, uncontrolled hypertension, autoimmune disease requiring daily use of ≥ 500 mg hydrocortisone or equivalent glucocorticoids, etc.