Intraoperative Dexmedetomidine Infusion in Endovascular Intervention for Aneurysmal Subarachnoid Hemorrhage

Launched by TANTA UNIVERSITY · Apr 2, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the use of a medication called dexmedetomidine during surgery for patients with a specific type of brain bleeding known as aneurysmal subarachnoid hemorrhage. The goal is to see how this medication affects the surgery and recovery process for patients undergoing an endovascular intervention, which is a less invasive procedure that helps treat blood vessel issues in the brain.

To participate in this trial, individuals must be over 18 years old, of any gender, and have a certain level of health as assessed by their anesthesia provider (classified as ASA I-III). They should have an unruptured subarachnoid hemorrhage confirmed by a special imaging test. However, there are several conditions that would exclude someone from joining, such as having other types of brain bleeding, serious heart or kidney problems, or a history of significant brain injury. Participants in the trial can expect to receive the dexmedetomidine infusion during their surgery and will be monitored closely to see how it impacts their surgery and recovery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged \>18 years.
• • Both sexes.
• • American Society of Anesthesiologists (ASA) I-III
• • Unruptured subarachnoid hemorrhage (SAH) confirmed by digital subtraction catheter angiography (DSA) undergoing endovascular intervention with general anesthesia.
• Exclusion Criteria:
• • Subarachnoid hemorrhage (SAH) from a lesion other than a ruptured saccular aneurysm.
• • Intraventricular or intracerebral blood in the absence of localized thick or diffuse Subarachnoid hemorrhage (SAH).
• • No or localized thin subarachnoid hemorrhage (SAH) on computed tomography (CT).
• • Cerebral vasospasm on admission digital subtraction catheter angiography (DSA).
• • Hypotension (systolic blood pressure 90 mm Hg) refractory to fluid therapy.
• • Neurogenic pulmonary edema.
• • Cardiac failure requiring inotropic support.
• • Severe or unstable concomitant condition or disease or chronic condition.
• • Kidney and/or liver disease.
• • Prior cerebral damage on computed tomography (CT) scan such as stroke (\>2 cm maximum diameter).
• • Pregnancy.
• • Traumatic brain injury.
• • Previously treated cerebral aneurysm.
• • Arterial venous malformation.
• • Pre-existing cerebrovascular disorder that will affect diagnosis and evaluation of Subarachnoid hemorrhage (SAH).
• • Ischemic heart disease or second or third-degree atrioventricular block.
• • Long-term abuse of alcohol, opioids, or sedative-hypnotic drugs.
• • Obesity (body mass index \[BMI\] \>30 kg/m2).