Adolescent Dysmenorrhoea as a Risk Factor for Chronic Pain: Clinical Cohort Study
Launched by UNIVERSITY OF OXFORD · Apr 2, 2024
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying how severe period pain, known as dysmenorrhea, in young women might be connected to the development of chronic pain later in life. Researchers want to see if the changes in the body that adult women experience with period pain are also present in adolescents who are just starting to have periods. This information could help doctors understand how quickly these changes happen and how period pain might lead to other types of pain, which could help in creating ways to prevent it.
The trial is looking for females aged 11 to 20 who have been having periods for at least a year and experience either moderate to severe period pain or no pain at all. Participants must be fluent in English and not currently using hormonal birth control. Those with a history of other chronic pain conditions or certain medical issues, such as pregnancy or previous cancer, may not be eligible. If you or your child participate, you can expect to help researchers learn more about dysmenorrhea and its effects, contributing to better understanding and care for future patients.
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • Participant (or parent/guardian of participant) is willing and able to give informed consent for participation in the study.
- • Female or assigned female at birth.
- • aged 11 - 20 years.
- • At least 6 periods per year since menarche.
- * During the study data collection period will be within one of the following time intervals since menarche:
- • 12 - 15 months
- • 36 - 39 months
- • 60 - 63 months
- • Reports either period pain or no pain with periods and scores appropriately on NRS (period pain: ≥4/10; no period pain: ≤3/10).
- • Not using hormonal therapies (i.e. contraceptives) currently and has not used previously.
- • Reasonably fluent in English.
- Exclusion Criteria:
- • Current or previous chronic pain condition other than dysmenorrhoea, including migraine.
- • Pregnant or breast-feeding.
- • Previous cancer diagnosis.
- • Contraindication to MRI
About University Of Oxford
The University of Oxford, a prestigious institution renowned for its excellence in research and education, serves as a leading clinical trial sponsor dedicated to advancing medical science and improving patient care. With a rich history of innovation and a multidisciplinary approach, the university leverages its extensive expertise in various fields, including medicine, public health, and biomedical research, to conduct rigorous clinical trials. Collaborating with healthcare professionals, industry partners, and regulatory bodies, the University of Oxford aims to translate groundbreaking research findings into effective therapies and interventions, contributing to the global effort of enhancing health outcomes.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Oxford, Oxfordshire, United Kingdom
Patients applied
Trial Officials
Katy Vincent, MRCOG, DPhil
Principal Investigator
University of Oxford
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported