The Development of Tinnitus in Patients With SSNHL: Insights From fMRI and Metabolomics

Launched by THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIVERSITY · Apr 3, 2024

Keywords

ClinConnect Summary

The incidence rate of tinnitus is very high globally and shows an increasing trend year by year. Sudden sensorineural hearing loss (SSNHL) , a prevalent otolaryngological emergency, often coincides with tinnitus among its patient population. This condition can significantly impact individuals' interpersonal relationships, work performance, and daily functioning, ultimately leading to a diminished quality of life and even psychological disturbances, such as anxiety and depression. Consequently, it is imperative to expore the mechanisms underlying the emergence and chronicity of tinnitus foll...

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Eligibility criteria

• Inclusion Criteria:
• 1. Group of SSNHL with Tinnitus:
• • 1. Age between 18 and 65 years old;
• • 2. Meets the diagnostic criteria for SSNHL; untreated within 5 days after onset;
• • 3. Presence of tinnitus;
• • 4. Able to complete questionnaires independently and cooperate with fMRI and follow-up assessments.
• 2. Group of SSNHL without Tinnitus:
• • 1. Age between 18 and 65 years old;
• • 2. Meets the diagnostic criteria for SSNHL; untreated within 5 days after onset;
• • 3. Absence of tinnitus;
• • 4. Able to complete questionnaires independently and cooperate with fMRI and follow-up assessments.
• 3. Healthy Control:
• • 1. Age between 18 and 65 years old;
• • 2. Normal hearing screening results;
• • 3. Able to complete questionnaires independently and cooperate with fMRI and follow-up assessments.
• Exclusion Criteria:
• • 1. Previous diagnosis of otic organic diseases such as otitis media, cholesteatoma of the middle ear, Ménière's disease, acoustic neuroma, hereditary deafness, inner ear malformations, etc.; history of ear surgery; long-term exposure to noise; use of ototoxic drugs;
• • 2. Presence of brain organic diseases such as cerebral infarction, brain tumor, or contraindications for functional magnetic resonance imaging (fMRI) during nuclear magnetic resonance (NMR) examination;
• • 3. History of mental illness, including anxiety, depression, insomnia, etc.;
• • 4. Individuals unable to cooperate due to severe mental factors.