Bronchiectasis Prevalence in Patients With Primary Humoral Immunodefiency in Champagne-Ardenne Region, France

Launched by CHU DE REIMS · Apr 4, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how common bronchiectasis, a condition that affects the lungs, is in patients with primary humoral immunodeficiency (PHID) in the Champagne-Ardenne region of France. PHID includes types of immune system problems like common variable immunodeficiency, which makes it harder for the body to fight off infections. The study aims to understand more about how bronchiectasis develops in these patients, as it can lead to serious health issues like chronic infections and breathing problems.

To be eligible for this trial, participants must be adults who have been diagnosed with PHID, including specific types like common variable immunodeficiency or certain antibody deficiencies. They can participate whether or not they have lung issues already. Participants will undergo thoracic CT scans to help diagnose bronchiectasis and will be part of a study that seeks to improve understanding and management of this condition. This research is important because it may help identify patients who are at risk and improve future care for those with PHID.

Gender

ALL

Eligibility criteria

• inclusion criteria :
• * Patients with primary humoral immunodeficiency defined as following :
• • Common variable immunodeficiency : Marked decreased in IgG seric concentration \< 5 g/L and in IgA seric concentration or IgM seric concentration (-2SD), without secondary cause
• • IgG subclass deficiency : marked decrease (-2SD) in at least one IgG subclass (IgG1, 2, 3 et 4) with or without IgA or IgM deficiency
• • Selective IgM Deficiency : isolated decrease un IgM seric concentration \<0.3g/L, without IgG or IgA deficiency
• • Adult patients
• • Patients with or without previously identified pulmonary complications
• • Patients agreeing to participate to the study
• • Patients insured under the French social security system
• Non-inclusion criteria :
• • Patients\< 18 years of age
• • Patients protected by law
• • Patients for whom CT scan is not feasible (claustrophobia, obesity...)
• • Pregnant women