Oropharynx (OPX) Biomarker Trial

Launched by MAYO CLINIC · Apr 4, 2024

Keywords

ClinConnect Summary

The Oropharynx Biomarker Trial is a research study focused on finding a specific biological marker linked to certain types of throat cancer caused by the human papillomavirus (HPV). The goal is to determine if this marker is present when the cancer is there and absent when it is not. This could help doctors better understand and diagnose these cancers in the future. The trial is currently recruiting participants aged 18 and older, who have been diagnosed with HPV-related oropharyngeal squamous cell carcinoma or certain other types of oral cavity cancers.

To join the study, participants will need to provide consent and undergo specific testing on their tumor samples. They should also be willing to return for follow-up visits at the Mayo Clinic for standard check-ups during the study. This trial is an important step in improving the way these cancers are diagnosed and treated, and it offers the chance for patients to contribute to valuable research that could benefit many others in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years
• • Able to provide written consent
• * Groups 1-3:
• • Must undergo p16 staining on biopsy for enrollment
• • Patients with \< 70% of tumor cells positive for p16 will be considered p16 negative
• • Must undergo HPV16 family in situ hybridization (ISH) and/or RNA on biopsy or surgical specimen, unless amount of tissue is too small to have conclusive HPV ISH testing done on it
• • Willingness and intent to return in person to enrolling institution for follow-up (during the Active Monitoring Phase of the study) for at least 2 of the standard follow-up time points for a total of 3 time-points including pre-treatment. A participant who does not return in person to Mayo Clinic Rochester for every standard of care post-treatment follow up will not be considered deviating from the protocol
• * Group 4:
• • Clinical suspicion or histopathologic diagnosis of head and neck cancer or neoplasm
• • Primary salivary neoplasm
• • Primary thyroid neoplasm
• • Primary head and neck neoplasm
• • Multi-cancer early detection (MCED) testing concerning for cancer
• • Patient has given permission to give his/her tumor/tissue/blood/saliva sample for research testing
• • Ability to complete questionnaire(s) by themselves or with assistance
• Exclusion Criteria:
• • Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm.
• * Groups 1-3:
• • Other active malignancy ≤ 5 years prior to registration
• • EXCEPTIONS: Non-melanotic skin cancer, non-metastatic thyroid cancer, non-metastatic prostate cancer, carcinoma-in-situ of the cervix, HPV+ oropharyngeal squamous cell carcinoma (SCC) (which can be enrolled in group 3)
• • NOTE: If there is a history of prior malignancy, they must not be receiving other specific treatment for their cancer
• • History of any head and neck malignancy, other than the tumor for which they are being treated
• * Group 4, Cohort A, B, C:
• • Other active malignancy ≤ 5 years prior to registration
• • EXCEPTIONS: Non-metastatic prostate cancer, carcinoma-in-situ of the cervix, non metastatic cutaneous basal cell carcinoma
• • NOTE: If there is a history or prior malignancy, they must not be receiving other specific treatment for their cancer
• • History of any head and neck malignancy, other than the present neoplasm
• * Note these are clarifications of inclusion into Group 4, Cohorts D and E:
• • Presence of other active malignancy or recurrent head and neck neoplasms are allowed in this arm
• • Receipt of cancer specific therapy for other malignancy is allowed in this arm