Aprepitant Treatment to Prevent Postoperative Nausea and Vomiting in Children Undergoing Scoliosis Surgery

Launched by IWK HEALTH CENTRE · Apr 9, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a medication called Aprepitant, which is being tested to see how well it prevents nausea and vomiting in children after they have surgery for scoliosis, a condition that causes the spine to curve. The trial is currently looking for participants who are between the ages of 8 and 19, weigh more than 40 kg, and are scheduled to undergo a specific type of surgery called posterior spinal instrumentation and fusion, which involves fusing at least six vertebrae in the spine.

If your child qualifies and decides to participate, they will receive Aprepitant before their surgery to help reduce the chances of feeling sick afterward. The trial is open to all genders and aims to ensure the safety and effectiveness of this treatment in a younger population. Participating in this study could help improve care for future children undergoing similar surgeries. If you have any questions or concerns about participation, the research team will be available to provide more information.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Posterior Spinal Instrumentation and Fusion (PSIF) for idiopathic scoliosis
• • The fusion must include at least 6 vertebral levels.
• • Children greater than or equal to 8 years old, and less than 19 years old on the day of surgery
• • Weight \> 40kg - for ease of pharmacy preparation (PONV dose 1mg per kg to max 40mg)
• Exclusion Criteria:
• • Patient/ Parent refusal
• • Hypersensitivity to Aprepitant or any ingredient in the formulation or oral solution. (previous allergy or adverse reaction to Aprepitant)
• • Developmental delay as reported by parents
• • Pregnant - Pregnancy test done as standard of care pre-operative
• • Severe systemic disease ASA classification III or greater
• • Concurrent use of any medication with severe interaction with Aprepitant as outlined in product monograph.
• • Neuromuscular or congenital scoliosis
• • Inability to take PO medications