Fertility Preservation and Pregnancy and Offspring Health Outcomes in Female Cancer

Launched by THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIVERSITY · Apr 7, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of fertility preservation on women with cancer who want to have children in the future. Researchers want to find out if women who take steps to preserve their fertility before starting cancer treatment, like freezing eggs or embryos, have better chances of having healthy babies compared to those who do not. The study will include around 2,800 women aged 20 to 40 who have been diagnosed with certain types of cancer and wish to have children later on.

To participate, women need to have a confirmed cancer diagnosis and express a desire to have children, whether they have given birth before or not. However, women with certain medical conditions that may affect pregnancy, or those whose cancer treatment might prevent them from having children, will not be eligible. Participants can expect to be part of a supportive environment where their health outcomes, along with those of their future children, will be carefully monitored and analyzed throughout the study. This trial is currently recruiting participants at the Clinical Center of Reproductive Medicine in Nanjing, China.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Tumor confirmed (main focus: breast cancer, hematological disease/lymphoma, gynecological tumor (ovarian cancer), boundary tumors, nasopharyngeal cancer, colorectal cancer, and other tumors that require anti-tumor treatment;
• • 2. Having a desire for future fertility(including women who have already given birth);
• • 3. Age: 20-40 years old (patients planning to freeze their eggs are ≤35 years old, and those planning to freeze their embryos are ≤40 years old);
• • 4. Consent.
• Exclusion Criteria:
• • 1. Patients with congenital or acquired uterine abnormalities, severe intrauterine adhesions, and other diseases that have a clear impact on pregnancy;
• • 2. Those with assisted reproductive technology and pregnancy contraindications;
• • 3. Tumors that are not suitable for pregnancy after multidisciplinary discussions on tumor fertility;
• • 4. Clinical diagnosis of POI (premature ovarian insufficiency).