Driving Pressure-guided Lung Protective Ventilation

Launched by YONG LIN, PHD · Apr 9, 2024

Keywords

ClinConnect Summary

This clinical trial, called "Driving Pressure-guided Lung Protective Ventilation," is looking into a new way to help patients breathe better after surgery for a serious heart condition known as acute type A aortic dissection. The main goal of the study is to see if using a specific method of lung ventilation can lower the chances of patients experiencing low oxygen levels in the days following their surgery. Low oxygen levels can make recovery more difficult, so finding ways to prevent this is very important.

To participate in this trial, patients should be between 14 and 70 years old and must be scheduled for surgery to repair their aortic dissection. They need to be able to understand and agree to participate in the study. However, some patients may not be eligible if they have certain health issues, like severe lung problems or heart failure. Those who do join the trial can expect to receive careful monitoring and support throughout their recovery process to see if this new approach helps improve their breathing and overall recovery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Able to sign Informed Consent and Release of Medical Information Forms;
• • 2. Age ≥ 14 years and ≤ 70 years old;
• • 3. Being confirmed the diagnosis by chest computed tomography angiography and receiving the surgical repair of acute type A aortic dissection.
• Exclusion Criteria:
• • 1. Age \< 14 years or \> 70 years old;
• • 2. Sepsis before surgery;
• • 3. Chronic pulmonary disease including lung infection or asthma requiring long-term pharmacotherapy;
• • 4. History of lung tumor;
• • 5. Obstructive sleep apnea hypopnea syndrome requiring long-term noninvasive mechanical ventilation support;
• • 6. Heart failure requiring catecholamines or invasive mechanical ventilation support;
• • 7. Body mass index \> 30 Kg·m-2;
• • 8. Being reluctance to participate this study.