Functional and Phenotypic Characterization of Monocytes in Myeloproliferative Syndromes

Launched by UNIVERSITY HOSPITAL, ANGERS · Apr 9, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how certain immune cells called monocytes behave in patients with specific blood disorders known as myeloproliferative neoplasms, including Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis. The goal is to better understand the characteristics and functions of these cells in people who have not yet started treatment for their condition.

To be eligible to participate, you must be diagnosed with one of these conditions according to recent guidelines and not have received any treatment for your blood disorder at the time of testing. Participants will need to give their consent to join the study and be willing to share their information with a hospital database. Throughout the study, participants can expect to undergo sampling of their blood to help researchers gather valuable data. This study is currently recruiting participants of all genders aged 65 to 74, and it’s important to note that individuals with other blood cancers or those under 18 years old cannot take part.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of PV, ET, pre-myelofibrosis or primary myelofibrosis according to WHO 2022 criteria (including BOM for ET, premyelofibrosis and primary myelofibrosis)
• • Patient who has not received treatment specific to hemopathy at the time of sampling
• • Obtaining the signature of consent to participate in the study
• • Patient having consented to be included in the "Malignant Hemopathy" collection of Angers University Hospital and in FIMBANK database
• Exclusion Criteria:
• • Person not affiliated to a social security scheme or beneficiary of such a scheme
• • Patient with another hemopathy or another active cancer at the time of diagnosis
• • Minor patient at diagnosis (\< 18 years old)
• • Patient not capable or without agreement from the guardian or legal representative