Effects of Different Remineralization Agents on Molar Incisor Hypomineralization Defects: a Randomized Clinical Study

Launched by UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO · Apr 8, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how well different types of treatments can help improve the appearance and health of teeth in children with a condition called Molar Incisor Hypomineralization (MIH). MIH causes white or brown spots on the teeth, which can be concerning for both children and their parents. The researchers want to compare the effectiveness of three remineralization treatments: fluoride varnish, Clinpro™ White Varnish, and a special paste that contains milk proteins. The trial is taking place in Mexico and aims to help children aged 6 to 12 years who have at least one affected tooth.

To participate in the study, children need to be between 6 and 12 years old, live in the study area, and have mild or moderate MIH on at least one permanent tooth. Parents must agree to let their child participate, and the child must not have any allergies to milk proteins. The study will not include children with more severe dental issues or those who are not able to use the treatments properly. If eligible, participants can expect to receive one of the treatments and help researchers learn more about how to better address this dental condition in children.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Children between 6 to 12 years
• • They live in the selected study area
• • Have at least one permanent incisor or molar with mild or moderate MIH (creamy white and/or yellow or brown opacities)
• • That their parents authorize participation in the study through informed consent.
• • No proven or suspected allergy and/or sensitivity to milk protein, as it is a component of the CPP-ACP product.
• Exclusion Criteria:
• • Defects in enamel development related to syndromes, dental fluorosis, amelogenesis imperfecta, dentinogenesis imperfecta.
• • Presence of orthodontic appliances.
• • Teeth with MIH with restorations, or severe MIH (affected enamel develops post-eruptive enamel breakdown), or carious lesions classified as score \>0 according to the ICDAS.
• • Children who do not show cooperation in the use of remineralizing agents.