Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression

Launched by JAKUB ANTCZAK · Apr 9, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called rTMS, which stands for repetitive Transcranial Magnetic Stimulation. This treatment is being tested to see if it can help improve symptoms of depression, particularly issues with thinking, enjoyment in life, and sleep. While the main symptom of depression is a low mood, many people also struggle with memory problems and sleep difficulties, which can make their situation harder to manage. The trial will look at how rTMS applied to two different areas of the brain can help with these additional symptoms in people diagnosed with unipolar depression or bipolar disorder.

To be eligible for this study, participants should be experiencing a moderate to severe episode of depression without any severe mental health issues like psychosis. They should also have trouble with memory and concentration related to their depression. The age range for participants is quite broad, from 18 to 75 years old, and both men and women can join. If someone is interested in participating, they can expect to receive rTMS treatment, and the study will monitor how their mood and other symptoms change over time. It's important to know that certain health conditions or risks, such as having ferromagnetic materials in the head or a history of recent suicidal thoughts, would prevent someone from participating in the trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • severe or moderate depressive episode (according to international classification of diseases (ICD)-10) without psychotic symptoms at the time of inclusion
• • Hamilton Depression Rating Scale between between 20 and 35 points at inclusion
• • The score in the Athens Insomnia Scale eight or more
• • The score of three or more points in items 4 and 21 of the Beck Depressions Inventory 2
• • Complaining about problems with memory and concentration timely related with the onset of depression
• Exclusion Criteria:
• • Contraindications to transcranial magnetic stimulation, including ferromagnetic elements in head, pregnancy and epilepsy
• • Psychotic symptoms at the time of inclusion
• • Suicidal ideations and/or attempts within three months prior to inclusion