Screening for AL Amyloidosis in Smoldering Multiple Myeloma

Launched by TUFTS MEDICAL CENTER · Apr 10, 2024

Keywords

ClinConnect Summary

This clinical trial is looking into a condition called light-chain amyloidosis (AL), which can develop in patients with smoldering multiple myeloma (SMM), a type of blood cancer that often doesn't require immediate treatment. Researchers want to find out if screening for AL amyloidosis early, before symptoms appear, can help diagnose the condition sooner. The study will involve about 400 patients aged 40 and older across 15 medical centers, and it aims to create a tool that can help predict the likelihood of developing AL amyloidosis based on specific test results.

To participate in this trial, you need to be at least 40 years old and diagnosed with smoldering multiple myeloma, with certain blood test results indicating higher levels of specific proteins. Unfortunately, younger patients or those with a previous amyloid diagnosis cannot join. If you qualify and choose to participate, you can expect to undergo screening tests and provide information that may help improve diagnosis and treatment for others in the future. It's important to know that this study is still recruiting participants, and your involvement could contribute to significant advancements in understanding these related conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients 40 years of age and older
• • diagnosed with Smoldering Multiple Myeloma
• • dFLC greater than 23 mg/L
• • abnormal FLC ratio
• • If the patient has an eGFR less than 50 mL/min/1.73m2, the FLC ratio is inconsequential. The patient only needs to meet the age and dFLC criterion.
• Exclusion Criteria:
• • Patients younger than 40 years of age are not eligible
• • Patients with a previous finding of amyloid in other biopsies will not be included
• • Adults unable to consent are not eligible, including the cognitively impaired Pregnant women, pregnant minors, minors (i.e., individuals who are not yet adults), wards of the state, non-viable neonates, neonates of uncertain viability, and prisoners are not eligible