Systemic Lupus Erythematosus and Chlordecone Impregnation in Martinique

Launched by UNIVERSITY HOSPITAL CENTER OF MARTINIQUE · Apr 10, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the possible link between exposure to a pesticide called chlordecone and the development of kidney problems in patients with systemic lupus erythematosus (SLE), a disease that affects the immune system and can lead to serious health issues. Chlordecone has been found in the environment in Martinique and has been associated with various health risks. Researchers want to see if patients with lupus who have been exposed to this pesticide have a higher chance of developing kidney damage, which is a common and serious complication of SLE.

To participate in the trial, individuals must have been diagnosed with systemic lupus erythematosus and have been under treatment at the internal medicine department of the Martinique University Hospital for at least three years. They also need to have lived in Martinique or Guadeloupe for at least a year and give their consent to take part in the study. Participants will undergo tests to confirm their kidney health and may have their exposure to chlordecone assessed. This research aims to better understand the impact of environmental factors on lupus and improve patient care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with systemic lupus erythematosus according to the ACR 1997 or ACR/EULAR 2019 criteria,
• • Present in the active line of the internal medicine department of the Martinique University Hospital since 2005,
• • Whose illness has been progressing for at least 3 years,
• • Living in Martinique or Guadeloupe for at least 1 year,
• • Patients who have given their free, informed and written consent.
• Exclusion Criteria:
• • Patients for whom kidney disease cannot be authenticated or ruled out (refusal, contraindication or impossibility of renal biopsy),
• • Patients without social security coverage,
• • Current legal protection,
• • Patients who have not given their consent to the use of their data,
• • Pregnant or breastfeeding women.