Adding Urea to the Final Dialysis Fluid

Launched by UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · Apr 10, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring a new way to help patients with advanced kidney failure who are experiencing severe issues like very high potassium levels or acid buildup in the blood. The study is testing whether adding urea to the fluid used during dialysis can help lower these dangerous levels without causing a condition called disequilibrium syndrome, which can happen if the blood urea drops too quickly. By finding a safer method to perform aggressive dialysis, the goal is to better manage these patients' health while reducing risks.

To be eligible for this trial, participants need to be between 65 and 74 years old and must have high levels of serum urea (greater than 120) and either high potassium levels (greater than 5.5) or low carbon dioxide levels (less than 15). They should also require dialysis treatment. However, this trial is not for children or those who need a specific type of continuous dialysis called CRRT. If someone qualifies and chooses to participate, they will receive careful monitoring and treatment as part of this important study to improve dialysis methods.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Serum Urea \> 120
• • Serum Potassium \> 5.5 or serum CO2 \< 15 or need for aggressive dialysis due to toxic ingestion
• • need for dialysis
• Exclusion Criteria:
• • Pediatric
• • need for CRRT