The Acute T-Rex (Timing of Resistance Exercise) Study

Launched by UNIVERSITY OF UTAH · Apr 10, 2024

Keywords

ClinConnect Summary

The Acute T-Rex Study is looking at how the timing of resistance exercise—either in the morning or evening—affects insulin sensitivity and sleep in adults who may be at risk for Type 2 diabetes. Insulin sensitivity is how well your body uses insulin to manage blood sugar levels, which is important for preventing diabetes. In this study, participants will perform resistance exercises in the morning, about 1.5 hours after waking up, or in the evening, about 11 hours after waking. After a short break, they will switch to the other time of day and see how it affects their body. The researchers believe that exercising in the evening may be better for improving insulin sensitivity.

To participate, individuals must be generally healthy adults aged 50 to 74 with a body mass index (BMI) between 25 and 45, meaning they are considered overweight or obese. They should not have any major health conditions that are not controlled, like heart or kidney diseases, and should not be using weight loss medications. Participants will complete their exercises in a lab, sleep overnight, and have their blood sugar levels tested the next day. This study could help identify the best time of day for resistance exercise to lower the risk of developing Type 2 diabetes, which is important for many people.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Men and women, all ethnicities, aged 50-74 years
• • BMI ≥25 kg/m² and \<45 kg/m²
• • Weight stable (less than 5% change in the past 6 months)
• • Generally healthy individuals
• • Not meeting recommended activity guidelines for aerobic or resistance exercise
• Exclusion Criteria:
• • Uncontrolled cardiovascular, metabolic, renal, or pulmonary disease
• • Cancer treatment in the past 5 years
• • Untreated thyroid disease or other medical conditions affecting weight or energy metabolism
• • Current use of weight loss medication or other medications likely to impact energy balance
• • Bariatric surgery or extensive bowel resection in the past 2 years
• • Current or recent history (past 2 years) of eating disorder
• • Diagnosis of insomnia, sleep apnea, or other sleep and circadian disorders
• • Non-English speaking
• • HbA1c \>6.5%