Orthopaedic Specimen Pathology and Early Diagnosis of ATTR Cardiopathy (ATTR-ORTHO)

Launched by INSTITUT MUTUALISTE MONTSOURIS · Apr 10, 2024

Keywords

ClinConnect Summary

The ATTR-ORTHO clinical trial is studying a condition called ATTR amyloidosis, which can affect the heart and other parts of the body. Specifically, the trial aims to find out how often ATTR amyloid is found in patients who are having surgery for conditions like carpal tunnel syndrome, lumbar spine stenosis, or hip and knee replacements due to arthritis. Researchers will look at tissue samples taken during surgery to see if they contain ATTR deposits and will also check if these patients have any heart involvement. They hope to identify any signs that might predict the presence of ATTR before surgery.

To be part of this study, you need to be at least 50 years old and undergoing one of the specified surgeries. If you participate, you can expect a thorough medical check-up before your surgery, including tests like an ECG (a heart test), blood tests, and imaging studies. If you have ATTR amyloidosis, the researchers will connect you with a specialized center for further monitoring and care. This study is important because it could help doctors identify ATTR amyloidosis earlier, which could lead to better management of the condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. patients aged 50 or over
• • 2. having signed an informed consent form
• • 3. undergoing surgery for
• • 1. idiopathic carpal tunnel syndrome
• • 2. or lumbar spinal canal stenosis
• • 3. or prosthetic replacement of a hip or knee for primary osteoarthritis
• Exclusion Criteria:
• • 1. secondary carpal tunnel syndrome (inflammatory rheumatism, diabetes, hypothyroidism, etc.)
• • 2. Indication of prosthesis for a condition other than primary osteoarthritis.
• • 3. Known amyloidosis
• • 4. Refusal of consent
• • 5. Inability to understand the study
• • 6. Age \< 50 years