The Cerebral Microcirculation Diseases and Coronary Microcirculation Disease Study

Launched by WEIJING WANG · Apr 11, 2024

Keywords

ClinConnect Summary

This clinical trial, called the Cerebral Microcirculation Diseases and Coronary Microcirculation Disease Study, is exploring the connection between two serious health conditions: coronary artery disease (which affects the heart) and cerebrovascular disease (which affects the brain). Researchers want to understand how problems in the small blood vessels (microcirculation) of the heart and brain might be linked, especially in patients who have narrowed blood vessels in the heart. The study focuses on adults aged 45 to 80 who have stable coronary artery issues but do not have certain serious conditions that could affect their ability to participate.

If you join this study, you will help researchers learn more about how these two diseases may be related. Participants will undergo tests to look at their heart and brain health. It's important to note that there are specific criteria for joining, such as not having had a recent heart attack or certain heart conditions. Your participation could contribute valuable information that might help improve understanding and treatment of these diseases in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Informed Consent available.
• • Age 45-80 years.
• • Stable coronary lesions.
• • target vessel with intermediate coronary lesion (40-80% diameter stenosis and FFR ≥0.8； or severe stenosis（\>80%）after successful PCI and FFR ≥0.8
• Exclusion Criteria:
• • Previous myocardial infarction in the territory of distribution of the target vessel.
• • Aortic valve stenosis (moderate or severe) .
• • Severe left ventricle hypertrophy.
• • Left ventricle moderate systolic dysfunction (EF \< 35%).
• • Contraindications to adenosine.
• • Previous CABG (Coronary artery bypass grafting) with permeable grafts.
• • Contraindication to stent implantation.
• • Severe anemia.
• • Unilateral or bilateral carotid artery stenosis (\> 50%).
• • Unilateral or bilateral middle cerebral arteries (\>50%).
• • Previous cognitive decline, baseline MoCA less than 16 points.
• • Coagulopathies or chronic anticoagulation.
• • Platelets \< 75000 o \> 700.000.
• • Previous stroke or intracranial hemorrhage.
• • Contraindication to MRI.
• • Chronic Renal Failure contraindicating gadolinium infusion during MRI: estimated glomerular filtration rate (eGFR) \< 60 ml/min), hemodialysis, previous renal transplantation.
• • Pacemaker/ Implantable Cardioverter Device with contraindication to MRI.
• • Planned cardiac surgery.
• • Life expectancy \< 1 years.