A Study Collecting Health Information to Understand and Prevent Gastric Cancer

Launched by MEMORIAL SLOAN KETTERING CANCER CENTER · Apr 12, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how to better understand and prevent gastric cancer, which can develop from certain conditions like gastric atrophy, intestinal metaplasia, and dysplasia. The researchers are creating a registry, a type of database, that will include people who have these precursor conditions, as well as healthy individuals and those who already have gastric cancer. By comparing these groups, the study aims to gather important health information that could help in the prevention and treatment of gastric cancer.

To participate, you need to be at least 18 years old and able to read and understand English. You may qualify if you have been diagnosed with one of the precursor conditions, or if you are a healthy individual with no history of gastric issues or cancer. Participants can expect to undergo an endoscopic procedure, which is a way for doctors to look inside the stomach using a thin, flexible tube with a camera. This research is important because it may lead to better ways to identify and manage the risk of gastric cancer in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years old
• • Able to read and understand English
• * Meet criteria for one of three potentially eligible study populations:
• • Individuals with gastric atrophy, gastric intestinal metaplasia, or dysplasia (increased risk): Had a previous diagnosis of or have been diagnosed by the investigation team with gastric atrophy, gastric intestinal metaplasia, or dysplasia of the gastric mucosa on pathology review from an endoscopic biopsy. Individuals who have a prior history of early gastric cancer may be included, if they were treated endoscopically and have no evidence of disease. Individuals who have a prior history of a cancer other than upper gastrointestinal cancer may also be included, if they have no evidence of disease for at least 1 year prior to study enrollment and are not undergoing active treatment for any malignancy at any time throughout the study period.
• • Healthy controls (average risk): Individuals with no history of cancer or gastric precursor lesions undergoing a clinically indicated endoscopy at MSK for workup or dyspepsia or reflux
• • Gastric cancer cases: Individuals with a known diagnosis of early gastric adenocarcinoma undergoing surgical resection at MSK
• Exclusion Criteria:
• • Age \< 18 years old
• • Women who are pregnant (may be enrolled after delivery)
• • Individuals with a prior history of upper gastrointestinal surgery or a prior cancer who are undergoing active treatment for malignancy or have been diagnosed within 1 year prior to the study enrollment. (This does not include incidentally diagnosed primary gastric adenocarcinoma identified during study follow up. Individuals diagnosed with gastric carcinoid limited to the stomach will also be included, given their ongoing parallel risk for gastric adenocarcinoma.)
• • Have severe comorbidities with expected survival time \<2 years or which would prevent them from undergoing routine elective EGD (at the discretion of the patient's provider and the study team)