Evaluation of the HPA Axis in Patients With Vasoplegic Syndrome After Cardiac Surgery
Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Apr 16, 2024
Trial Information
Current as of August 25, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is investigating how a condition called vasoplegic syndrome affects the adrenal glands in patients who have undergone cardiac surgery. Vasoplegic syndrome can cause low blood pressure and is often seen after heart surgeries. The study aims to understand how this condition impacts the body's stress response, particularly by looking at specific hormone levels in the blood. This could help doctors learn more about how to treat patients who experience this syndrome after surgery.
To participate in the trial, you must be at least 18 years old and scheduled for heart surgery that requires a heart-lung machine. Participants must also be able to give their consent or have a trusted person who can make decisions on their behalf. If you have used certain medications recently or have specific health issues related to the adrenal glands or brain, you may not be eligible. If you join, you can expect to provide blood samples for testing, which will help researchers gather important information about adrenal function in this context.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Age ≥ 18 years
- • Scheduled cardiac surgery with extracorporeal circulation
- • Patient or trusted person or legal representative informed and having expressed non-opposition to participation in the study.
- Exclusion Criteria:
- • Previous treatment within the last 3 months with glucocorticoids, azoles (Fluconazole, Voriconazole), phenytoin, rifampin, glitazones (Rosiglitazone or Pioglitazone), imipraminics (Clomipramine, Imipramine, Amitriptyline), barbiturates (Primidone, Phenobarbital, Thiopenthal) or phenothiazines (Chlorpromazine, Cyamemazine).
- • Adrenal or intracranial pathology affecting the hypothalamic-pituitary axis.
- • Cardiac transplants.
- • Post-operative mechanical extracorporeal assistance.
- • Patient deprived of liberty by judicial or administrative decision.
About Assistance Publique Hôpitaux De Paris
Assistance Publique - Hôpitaux de Paris (AP-HP) is a leading public hospital system in France, renowned for its commitment to healthcare excellence and innovative medical research. As a prominent clinical trial sponsor, AP-HP plays a pivotal role in advancing medical knowledge and improving patient care through rigorous scientific investigations across a wide range of therapeutic areas. With a focus on collaboration and interdisciplinary approaches, AP-HP leverages its extensive network of hospitals and expert clinicians to facilitate high-quality clinical trials that adhere to the highest ethical and regulatory standards, ultimately aiming to translate research findings into tangible health benefits for diverse patient populations.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Paris, Ile De France, France
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported