A Clinical Trial of Soluble Fiber for Asthma

Launched by PHOENIX CHILDREN'S HOSPITAL · Apr 12, 2024

Keywords

ClinConnect Summary

This clinical trial is studying whether adding a type of soluble fiber, called NOVELOSETM 3490, can help improve asthma symptoms in children aged 6 to 17. The researchers want to learn how diet, specifically fiber intake, might affect asthma by looking at samples from participants, such as blood, stool, and nasal wash. If your child is eligible for the study, they will be randomly assigned to receive either the soluble fiber or a placebo (a drink with no active ingredient) for several weeks. Participants will also fill out a dietary questionnaire to assess their fiber intake.

To be eligible, your child should have been diagnosed with asthma in the last two years and must meet certain health criteria, including having a specific level of a marker in their breath that indicates asthma severity. They should not have had any emergency visits for asthma in the past month and must be able to return for a follow-up visit after 4 to 6 weeks. This trial is still recruiting, so if you're interested, it's a good opportunity to learn more about how diet might play a role in managing asthma.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Between ages 6-17
• • Asthma diagnosis within the last 2 years
• • Fractional excretion of exhaled nitric oxide (FeNO) \> 50 ppb OR a clinical history of environmental allergies as defined by a positive skin prick or positive specific immunoglobulin E (IgE) tests to aeroallergens
• • No emergency department visits in the past 1 month
• • Ability to consume a liquid drink of fiber or placebo
• • Ability to return for a 4-6 week follow-up visit
• • No special or unique diet
• Exclusion Criteria:
• • Cystic fibrosis
• • Bronchiectasis
• • Change in asthma medicines other than short acting bronchodilators planned over the next 4-6 weeks
• • Baseline estimated daily fiber intake less than or equal to 16 grams as determined by the ASA 24
• • Sibling of a participant already enrolled in the study