Mechanisms of Acute Kidney Injury in Severe Infections

Launched by UPPSALA UNIVERSITY HOSPITAL · Apr 15, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how severe infections, like sepsis, can lead to acute kidney injury (AKI). Researchers want to understand how blood flow to the kidneys and inflammation caused by certain immune cells, called neutrophils, affect kidney function in patients with sepsis. To do this, they will use a special imaging technique called positron emission tomography (PET) to take detailed pictures of the kidneys and measure how these factors contribute to kidney damage.

To take part in this study, you need to be over 30 years old and have sepsis with at least stage 1 AKI. Healthy volunteers who meet the same age requirement and have normal kidney function can also participate. Throughout the study, participants will undergo imaging with a PET-CT camera, which will capture both pictures of the kidney's structure and information about blood flow and inflammation. It’s important to know that people with chronic kidney disease, those on dialysis, or anyone who is pregnant or breastfeeding cannot join this trial. If you’re interested in learning more or if you think you might qualify, please talk to your healthcare provider.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with sepsis and AKI
• • \> 30 years
• • At least AKI stage 1 according to KDIGO where the last plasma creatinine is measured within 24 hours of the examination
• • Healthy volunteers
• • \> 30 years
• • No previously known kidney disease
• • Normal plasma creatinine value
• Exclusion Criteria:
• • Chronic renal failure (CKD stage \>3a) or dialysis
• • Instability in vital functions that makes PET-CT examination unsuitable
• • Claustrophobia or other reasons that make the patient unable to lie still during the examination.
• • Pregnancy and breastfeeding