The Efficacy of Weight-loss Diet Decision-making Based on Initial Gut Metabolic Modules (GMMs)

Launched by TAIPEI VETERANS GENERAL HOSPITAL, TAIWAN · Apr 16, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how different types of diets can help people lose weight, especially by looking at the role of gut bacteria in our bodies. Researchers want to find out if a test that examines gut bacteria (called Gut Metabolic Modules, or GMMs) can help predict which diet might work best for someone trying to lose weight. Participants will follow either a low-carb diet, which is high in healthy fats, or a low-fat diet that includes whole grains, both designed to have the same number of calories. The goal is to see how effective these diets are for weight loss and if gut bacteria play a role in that process.

To take part in this study, you should be aged between 18 and 65 and have a body mass index (BMI) of 24 or higher, which indicates being overweight or obese. However, you cannot have any serious health conditions or be on certain medications, and you should not have recently changed your weight or participated in other weight loss programs. If you join the trial, you can expect to follow one of the diets for a specific period and undergo testing to see how your body responds. This research is important because it could help tailor weight loss strategies based on individual gut health, making weight loss more effective for many people.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with BMI \>=24 overweight and obesity without chronic disease or medication use.
• Exclusion Criteria:
• • a) Medication history of diabetes, hypertension, dyslipidemia, and cardiovascular diseases within two months.
• • b) Bodyweight change within three months before the study. (+4kg). c) Participate in weight loss programs in the preceding 12 months. d) Use ABX, PPI, NSAID, laxatives, oral contraceptives, and antipsychotics within two months.
• • e) Previous operations history for managing obesity (bariatric procedures and gastric bypass operation).
• • f) Current smoking: at least 20 monthly cigarettes for over half a year. g) Alcohol consumption (\> two glasses per day). h) Pregnancy, breastfeeding, chronic kidney dis-ease, autoimmune, viral chronic diseases (hepatitis C, B, HIV, etc.), and neoplastic diseases.
• • i) Consumption of vegetarian or unusual diets. The Institutional Review Board approved all study protocols at TVGH.