Natural History Study of Kaposi Sarcoma

Launched by NATIONAL CANCER INSTITUTE (NCI) · Apr 18, 2024

Keywords

ClinConnect Summary

This clinical trial, called the Natural History Study of Kaposi Sarcoma (KS), aims to learn more about how KS develops and why it might come back in some people. Kaposi sarcoma is a type of tumor caused by a virus and can appear mainly on the skin but may also affect other parts of the body, especially in people with weakened immune systems. The researchers want to collect information on the disease's progression and its impact on the immune system and different organs.

To participate, you must be at least 18 years old and have a confirmed diagnosis of Kaposi sarcoma. During the study, participants will undergo several evaluations, including physical exams, blood tests, imaging scans, and possibly biopsies (taking small tissue samples from tumors). You will have regular visits to the clinic over 18 months, with follow-up visits each year for up to 10 years. It's important to note that participants will continue their regular treatment for KS during the study. If you meet the eligibility criteria and are interested, this study could help improve understanding and treatment of Kaposi sarcoma.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • Participants must have histological KS confirmed by the Laboratory of Pathology (LP), NCI.
• • KS as assessed by cutaneous or oral KS lesions or other assessable KS disease.
• • Age \>=18 years.
• • ECOG performance status \<=4.
• • Ability of participant to understand and the willingness to sign a written informed consent document.
• EXCLUSION CRITERIA:
• • Participants with active KSHV-associated inflammatory cytokine syndrome (KICS), multicentric Castleman disease (MCD), or primary effusion lymphoma (PEL).
• • Participants with serious and/or uncontrolled severe intercurrent illness, such as opportunistic infections, that in the judgement of the investigator would preclude participation in the study.