Ultrasound Evaluations of Diaphragm and Intercostal Muscle to Predict the Failure of High-Flow Nasal Cannula Therapy

Launched by SHANGHAI ZHONGSHAN HOSPITAL · Apr 17, 2024

Keywords

ClinConnect Summary

This clinical trial is looking to see if ultrasound can help predict whether patients will respond well to High-flow Nasal Cannula (HFNC) therapy, which is a method of providing oxygen to people who are having trouble breathing. Researchers will use ultrasound to check how well the diaphragm and intercostal muscles (the muscles between your ribs) are working during the first day of treatment. The goal is to figure out if these muscle evaluations can help identify patients who might not benefit from this type of oxygen therapy.

To participate in this study, you need to be over 18 years old and require High-flow Nasal Cannula therapy. However, if you have had certain breathing support within the past month, have a history of specific muscle disorders, or are pregnant, you may not be eligible. If you join the study, you'll undergo ultrasound assessments to evaluate your muscle function while receiving HFNC therapy. This research hopes to improve patient care by understanding which patients may need different treatment sooner.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • more than 18 years old
• • needing High-flow Nasal Cannula oxygenation therapy
• Exclusion Criteria:
• • received mechanical ventilation, including invasive or noninvasive ventilation within one month prior to enrollment
• • history of neuromuscular disorders (e.g., myasthenia gravis, Guillain-Barre syndrome);
• • immediate endotracheal intubation is required (life-threatening hypoxemia)
• • extensive damage to the thoracic skin (e.g., burns) unable to undergo ultrasonography
• • pregnancy
• • attending physician deemed it inappropriate to participate in the trial.