Platelet Activation in Delayed Cerebral Ischemia Secondary to Aneurysmal Subarachnoid Hemorrhage

Launched by HOSPICES CIVILS DE LYON · Apr 16, 2024

Keywords

ClinConnect Summary

This clinical trial is examining the role of platelets, which are small cells in our blood that help with clotting, in a condition known as delayed cerebral ischemia. This condition can happen after an aneurysmal subarachnoid hemorrhage, which is bleeding in the brain caused by a burst blood vessel. The trial aims to better understand how platelets and the blood vessel lining interact over time, as this could help identify why some patients experience complications after the initial bleeding. By monitoring these changes, researchers hope to find ways to prevent further brain damage and improve patient outcomes.

To participate in this study, individuals must be adults 18 years or older who have been admitted to the neurological intensive care unit due to an aneurysmal brain bleed. They should also be able to provide consent or have a close relative who can consent on their behalf. It’s important to note that certain people, such as those with specific blood disorders or who are pregnant, cannot take part in the study. Participants will be closely monitored during their time in the hospital, and researchers will collect data to help understand how platelet activity may contribute to complications following a brain injury.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male and Female Adults ≤18 years of age.
• • Hospitalised in the neurological intensive care unit of the Pierre Wertheimer Hospital of the Hospices Civils de Lyon following an aneurysmal meningeal haemorrhage of any modified Fischer score, previously diagnosed by cerebral CT scan.
• • Patients admitted to the neurological intensive care unit or the NICU of the Pierre Wertheimer Hospital of the Hospices Civils de Lyon for an intra-parenchymal haematoma.
• • Patient who has been informed and has formulated his/her non-opposition, or close relative of the patient who has been informed and has formulated his/her non-opposition.
• • Affiliated to a social security scheme.
• Exclusion Criteria:
• • Non-aneurysmal SAH
• • Ischaemic stroke
• • Patients with previously known platelet function disorders
• • Pregnant or breast-feeding women
• • Patients under legal protection (guardianship, curatorship, safeguard of justice)
• • Patients under compulsory psychiatric care
• • Patients taking part in a study which may interfere with the present study