Italian iTTP Registry

Launched by FONDAZIONE LUIGI VILLA · Apr 17, 2024

Keywords

ClinConnect Summary

The Italian iTTP Registry is a clinical study designed to learn more about a serious condition called immune-mediated thrombotic thrombocytopenic purpura (iTTP). This condition affects the blood by causing low platelet levels and can lead to serious complications. The study will follow at least 132 patients who are experiencing their first episode of iTTP or a relapse over the course of three years. Researchers want to understand how the disease progresses and what outcomes patients experience.

To participate in this study, individuals must be at least 12 years old and have been diagnosed with an acute episode of iTTP, which is confirmed by specific blood tests. Participants will be asked to sign a consent form to join the study. Throughout the study, participants can expect regular follow-ups to monitor their health and gather important information about the disease. This research aims to improve knowledge about iTTP and ultimately enhance care for patients facing this condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with an acute iTTP episode (first event or relapse), defined by thrombocytopenia and microangiopathic hemolytic anemia, in the absence of alternative causes, and the presence of severe deficiency of ADAMTS13 activity (\< 10 IU/dL or \<10% of normal value) and anti-ADAMTS13 autoantibodies
• • Both male and female patients, aged 12 years or older
• • Patients who have signed the informed consent for the participation to the study
• Exclusion Criteria:
• • Patients who have not signed the informed consent for the participation to the study