Efficacy & Safety of Dry Powder Ivy Extract (Syrup Prospan) Versus NAC Among COPD Patients

Launched by NATIONAL UNIVERSITY OF MALAYSIA · Apr 17, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness and safety of two treatments for patients with Chronic Obstructive Pulmonary Disease (COPD): Dry Powder Ivy Extract (Syrup Prospan) and N-acetylcysteine (NAC). COPD is a serious lung condition that affects millions of people and can lead to frequent breathing problems and hospital visits. The goal of the trial is to see if these treatments can help reduce mucus and improve breathing, making it easier for patients to manage their symptoms and avoid worsening health.

To participate in this study, individuals must be at least 40 years old, have a confirmed diagnosis of stable COPD, and be able to complete a breathing test called spirometry. However, those with other serious lung conditions, recent heart problems, or certain sensitivities to medications are not eligible. Participants will have the opportunity to try one of the two treatments and will be closely monitored throughout the study to assess their health and any changes in their condition. This research is important as it may lead to better treatments for COPD and improve the quality of life for many patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participants with documented post bronchodilator FEV1/FVC \< 70 or \<LLN
• • Age 40 years and above
• • Able to perform spirometry
• • Participant with Stable COPD based on GOLD 2023 strategy
• Exclusion Criteria:
• • Diagnosis of other chronic lung diseases: Asthma, Asthma-COPD Overlap, Interstitial Lung Disease, Bronchiectasis, Lung Cancer
• • Participants with contraindication for spirometry: recent cardiac complications, major surgery, severe advanced respiratory disease, or those with cognitively or neurologically impairment
• • Hypersensitivity to acetylcysteine or any component of the formulation
• • Hypersensitivity to dry powder ivy extract
• • Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG (human Chorionic Gonadotropin) laboratory test
• • Participant on pre-existing regular mucolytics (at least 1 month prior)
• • Illiterate participants