Rehabilitation in Muscular Dystrophies From the Hospital Facility to the Home: Pilot Project [RIMUDI]

Launched by IRCCS EUGENIO MEDEA · Apr 19, 2024

Keywords

ClinConnect Summary

The RIMUDI trial is studying how rehabilitation can benefit people with muscular dystrophies, specifically conditions like Limb Girdle Muscular Dystrophy, Facio-Scapulo-Humeral Dystrophy, and Becker Muscular Dystrophy. The goal is to see if supervised exercise programs can improve muscle strength and overall health, even when done at home. Researchers believe that regular, controlled physical activity can help maintain muscle function and prevent deterioration, reversing the old belief that exercise could harm muscle cells.

To participate in this study, individuals aged between 65 and 74 with a confirmed genetic diagnosis of one of the muscular dystrophies mentioned may be eligible. They should be able to walk independently, even with some assistance, and have undergone a clinical evaluation at the research facility within the past year. Participants will be expected to commit to the rehabilitation program for six months and should not be receiving physical therapy elsewhere during that time. This trial aims to provide valuable insights into the benefits of exercise for those living with these conditions, potentially leading to better care and improved quality of life.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria:- definite genetic diagnosis of Limb Girdle Muscular Dystrophy: LGMD2A/R1(calpain 3 deficiency), LGMD2B/R2(dysferlin deficiency), LGMD2I/R9 (FKRP), LGMD2L /R11(ANOCTAMIN 5) or Facio Scapulo Humeral Dystrophy (FSHD) or Becker muscular dystrophy (BMD);
• • strength values at the level of the main antigravity muscles \> or equal to 3, according to the Medical Research Council (MRC) scale;
• • independent walking in a protected (internal) environment, even with assistance;
• • patients must have performed at least 1 clinical-functional evaluation at our facility in the year preceding the start of the trial.
• • They must express compliance with joining the project and must not be followed from a physiotherapeutic point of view elsewhere during the 6 months of participation in the project.
• Exclusion Criteria:
• • dilated or ischemic heart disease with Left Ventricle Ejection Fraction \<50%;
• • chronic respiratory failure with Forced Vital Capacity \< 40% predicted, nocturnal oxygen desaturation - \> 5% of nocturnal time spent with peripheral oxygen saturation levels \< 90).