Single-center Clinical Study on the Safety and Effect of Bronchoscopic Cryotherapy in Patients With Chronic Cough

Launched by GUANGZHOU MEDICAL UNIVERSITY · Apr 18, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called cryotherapy, which involves freezing certain areas in the lungs, to see if it can help people who have a chronic cough that lasts more than eight weeks. Chronic cough is a common problem that can be very frustrating and affects daily life. The researchers want to find out if this treatment can reduce the frequency and severity of coughing, as well as improve the quality of life for those suffering from it. They will also check if the treatment is safe to use.

To participate in this trial, individuals must be between 18 and 65 years old, have a chronic cough with no known cause, and be willing to commit to follow-up visits and procedures. Participants will undergo a routine examination that includes looking at their airways with a thin tube (bronchoscopy) and may receive cryotherapy treatment. Throughout the study, their health will be monitored, and they will have several follow-up appointments to check on their progress. It's important to note that people with certain health conditions or those who are pregnant cannot participate in this trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria(To be eligible, all of the following criteria must be met):
• • Age between 18 and 65 years, regardless of gender;
• • Patients with cough of unknown etiology or cause, lasting for more than 8 weeks;
• • Cough Visual Analogue Scale (VAS) score ≥ 50；
• • Willingness to provide voluntary informed consent and agree to follow-up;
• • The investigator believes that the overall status of the subjects does not affect the evaluation and completion of the trial.
• Exclusion Criteria(Any one of the following criteria must not be met to be eligible):
• • Presence of other diseases that may affect treatment efficacy and prognosis.
• • Severe underlying conditions such as heart, brain, or lung diseases.
• • Inability to tolerate bronchoscopy procedures and painless anesthesia.
• • Women who are pregnant, breastfeeding, or planning pregnancy.
• • Intravenous drug users.
• • Participation in or currently participating in other clinical studies involving drugs, devices, or other interventions within the month prior to enrollment.
• • Other conditions deemed unsuitable for inclusion in this study by the investigators, such as anatomical unsuitability, psychiatric disorders, or psychological disorders.