Non-steroidal Anti-inflammatory in Cardiac Surgery

Launched by CENTRE HOSPITALIER UNIVERSITAIRE, AMIENS · Apr 23, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the safety and effectiveness of non-steroidal anti-inflammatory drugs (NSAIDs) for managing pain after heart surgery. Researchers want to see if these pain-relief medications can be safely used in patients recovering from surgeries like aortic valve replacement or coronary artery bypass grafting. They believe that, despite concerns about possible side effects like increased bleeding or kidney problems, NSAIDs can be a safe option for treating pain right after surgery.

To participate in the trial, patients must be scheduled for specific types of heart surgery and be between the ages of 65 and 74. They also need to be part of the French national healthcare system and provide written consent to join the study. Participants can expect to receive NSAIDs as part of their pain management plan and will be monitored closely for any side effects. It's important to note that certain conditions, like being under 18, having a certain weight, or having specific medical histories, may prevent someone from being eligible to participate.

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Eligibility criteria

• Inclusion Criteria:
• • scheduled for cardiac surgery (aortic valve replacement, coronary artery bypass graft, mitral valve repair or replacement, intracardiac tumor, aortic root repair)
• • under cardiopulmonary bypass
• • Affiliation to the French national healthcare system
• • Written consent obtained
• Exclusion Criteria:
• • age\<18
• • weight\<50 kg
• • chronic use of NSAID
• • mini-invasive surgery
• • NSAID contraindication
• • NSAID allergy
• • Nefopam contraindication
• • Paracetamol contraindication
• • Tramadol contraindication
• • Urgent surgery
• • Endocarditis
• • Immunosuppressive drug
• • HIV infection with CD4\<200 mm3
• • Organ transplantation
• • Stage 4 or 5 chronic kidney disease
• • Gastro duodenal ulcer
• • Pregnancy
• • Depression
• • Auto immune disease