Effect of Aloe Vera Gel and Manuka Honey on Radiation Induced Oral Mucositis

Launched by AIN SHAMS UNIVERSITY · Apr 20, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how well Aloe Vera Gel and Manuka Honey can help manage a painful condition called radiation-induced oral mucositis, which can happen to patients receiving radiation therapy for head and neck cancer. The researchers want to find out if these natural products can reduce the symptoms of mucositis and also if they can change certain substances in saliva that are related to this condition. Participants will be asked to apply either Aloe Vera Gel, Manuka Honey, or a saline solution (a simple saltwater solution) three times a day during their radiation treatment and for six months afterward.

To be eligible for this study, participants must be between 20 and 70 years old, have a confirmed diagnosis of head and neck cancer, and be receiving radiation therapy that involves their mouth area. They should also have oral mucositis and be willing to participate in the study assessments. However, individuals with diabetes or those who have had recent radiation therapy in the past six months cannot take part. If you join the study, you’ll be helping researchers learn more about potential treatments for this challenging side effect of cancer therapy!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • a) Patients with a confirmed histologic diagnosis of H\&N malignancy who are referred to non-palliative radiotherapy in the oral cavity.
• • b) Patient who is receiving radiation therapy with IMRT or 3D techniques. c) Patients received 50-70 Gy of total radiation at the rate of 2 Gy/fraction daily and 5 fractions/week.
• • d) Patient who received concurrent chemotherapy with radiotherapy e) Presence of Oral Mucositis f) Age 20-70 years old g) Willing to participate in the study. h) Able to complete the study assessments.
• Exclusion Criteria:
• • a) Have a confirmed or medically treated diabetes mellitus b) Radiotherapy within the last 6 months prior to this study c) Vulnerable patients