Taiwan Registry of Hypertrophic Cardiomyopathy (THIC) Research Synopsis

Launched by FAR EASTERN MEMORIAL HOSPITAL · Apr 19, 2024

Keywords

ClinConnect Summary

The Taiwan Registry of Hypertrophic Cardiomyopathy (THIC) is a clinical trial focused on understanding hypertrophic cardiomyopathy (HCM), a heart condition that causes the heart muscle to thicken. This thickening can lead to serious issues like irregular heartbeats and heart failure. The study aims to gather information about how common HCM is in Taiwan, especially considering the unique genetic background of the population. Researchers will also look into related rare heart diseases, such as Fabry disease, which can have similar symptoms, making diagnosis tricky.

To join this study, participants need to be adults aged 20 and older who have been diagnosed with left ventricular hypertrophy, which is a key feature of HCM. They will undergo tests to confirm their condition and will need to agree to participate by signing an informed consent form. This research is currently recruiting, and participants can expect to contribute to a better understanding of HCM and related conditions, which could lead to improved diagnosis and treatment options for patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• 1. Presence of left ventricular hypertrophy (LVH) on echo/CMRI:
• • 2. maximal interventricular septal (IVST) and/or posterior wall thickness (PWT) ≥13 mm,
• • 3. apical wall thickness ≥15 mm or a ratio of apical to basal LV wall thickness of ≥ 1.3 at end-diastole, OR
• • 4. maximal LV wall thickness ≥ 15mm of ANY OTHER PART
• • 5. Male and female adult age ≥ 20 year-old
• • 6. Patients willing to comply with and sign the informed consent
• Exclusion Criteria:
• • 1. Patients refuse or unable to give informed consent
• • 2. Patients unlikely to comply with the protocol or unable to understand the nature and possible consequences of the program
• • 3. Co-arctation of the aorta, severe aortic stenosis, or severe LV pressure overload
• • 4. Athletic heart
• • 5. Non-compaction cardiomyopathy