Validation of New Diagnostic Indices to Simplify Hyponatremia Therapy Assessment in Patients on Thiazide Diuretics

Launched by UNIVERSITY HOSPITAL, BASEL, SWITZERLAND · Apr 19, 2024

Keywords

ClinConnect Summary

This clinical trial is examining two new methods, called aSID and ChU, to help doctors better understand and treat low sodium levels (known as hyponatremia) in patients taking a type of medication for high blood pressure called thiazide diuretics. The goal is to see if these new methods can help doctors identify the cause of low sodium levels and decide on the best treatment, potentially improving patient care compared to current methods.

To participate in the study, you must be at least 18 years old, hospitalized at University Hospital Basel, and have a low sodium level along with certain other health indicators. However, if you have severe health issues requiring immediate treatment, such as significant heart or liver problems, or if you are pregnant or breastfeeding, you won’t be eligible. Participants in the trial can expect close monitoring and care from the research team as they explore these new diagnostic methods. This study aims to make it easier for doctors to manage low sodium levels in patients on thiazide medications, ultimately leading to better treatment outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Hospitalized patients presenting at University Hospital Basel
• • aged 18 years or older
• • able to give informed consent as documented by signature
• • with serum sodium level \< 130 mmol/l and serum osmolality \< 300 mOsm/kg
• • with treatment with thiazide or thiazide-like diuretic
• Exclusion Criteria:
• • symptomatic hyponatremia in need of 3% hypertonic solution or intensive care treatment
• • inability or contraindications to undergo the trial (i.e., any acute severe cardiovascular event requiring an immediate intervention)
• • decompensated liver cirrhosis CHILD C
• • decompensated heart failure NYHA III or higher
• • severe valve impairment
• • untreated adrenal insufficiency
• • severe kidney disease in need of dialysis
• • pregnancy or breastfeeding
• • end of life care
• • inability to follow the study procedures (i.e., language problem, dementia or critical illness).