Glycemic Excursions in Patients With Type 1 Diabetes Mellitus Using Closed-loop Systems
Launched by UNIVERSITY HOSPITAL, MOTOL · Apr 19, 2024
Trial Information
Current as of August 27, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying how blood sugar levels, known as glycemic excursions, change in people with type 1 diabetes during different daily activities, such as driving, sleeping, working, exercising, and experiencing stress. The researchers want to compare the effects of two different treatment methods: one group uses a closed-loop insulin delivery system (like an insulin pump), while the other group uses multiple daily insulin injections along with a continuous glucose monitor (CGM).
To participate in this study, individuals must be at least 18 years old, have had type 1 diabetes for at least three years, and regularly drive (but not as a professional driver). Participants will be asked to complete some questionnaires about their experiences. The study is currently recruiting participants, and as a participant, you will help researchers understand how different diabetes management methods can affect blood sugar levels in everyday situations. If you have questions or want to know more about how to get involved, don't hesitate to reach out!
Gender
ALL
Eligibility criteria
- • Inclusion criteria
- Study group:
- • type 1 diabetes
- • patients aged ≥18 year
- • diabetes duration ≥3 years
- • regularly driving (non-professional drivers only)
- • treated with insulin pump MiniMed 780 G for at least 6 months with closed-loop setting treatment
- • willing to fill in the study questionnaires
- • signed patient's informed consent form
- Control group:
- • type 1 diabetes
- • patients aged ≥18 years
- • diabetes duration ≥3 years
- • regularly driving (non-professional drivers only)
- • treatment with multiple daily injections (MDI) of insulin therapy and the use of CGM for at least 6 months
- • willing to fill in the study questionnaires
- • signed patient's informed consent form
- • Exclusion Criteria (for study and control groups)
- • professional drivers
- • pregnancy
- • inability to be present at the follow-up visit
- • inability to complete the study questionnaires
- • participation in another clinical study within the last 3 months
About University Hospital, Motol
University Hospital Motol is a leading academic medical center dedicated to advancing healthcare through innovative research and clinical trials. Located in Prague, Czech Republic, the hospital is affiliated with Charles University and serves as a key institution for medical education and training. With a robust focus on patient-centered care, University Hospital Motol conducts a wide range of clinical studies across various specialties, aiming to improve treatment outcomes and enhance the understanding of complex medical conditions. The hospital's commitment to excellence in research, combined with its state-of-the-art facilities and multidisciplinary expertise, positions it at the forefront of clinical trial initiatives in the region.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Prague, , Czechia
Patients applied
Trial Officials
Jan Brož, MUDr., Ph.D.
Principal Investigator
Second Medical Faculty, Charles University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported