Effect of Frontal Transcranial Direct Current Stimulation on BDNF in Stroke Patients With Cognitive Impairment

Launched by THE SECOND AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIVERSITY · Apr 23, 2024

Keywords

ClinConnect Summary

This clinical trial is looking for a way to help stroke patients who are having trouble with their thinking and memory skills, known as cognitive impairment. The researchers want to see if a treatment called transcranial direct current stimulation (tDCS) can improve these patients' cognitive function and if it affects a protein called BDNF, which is important for brain health. Participants will receive standard stroke treatments along with the tDCS therapy, and the study will compare their thinking abilities and BDNF levels before and after treatment.

To be part of this study, patients should be between 40 and 80 years old and have had a recent stroke that has been confirmed by imaging tests like CT or MRI. They also need to show signs of cognitive dysfunction as assessed by a doctor. It’s important that participants can understand and cooperate during evaluations and treatments. If people have serious health issues that would make it hard for them to participate or have conditions that prevent them from safely receiving tDCS, they may not be eligible. Overall, this trial aims to find new ways to support stroke survivors in regaining their cognitive skills.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • (1)Stroke patients with CT or MRI imaging evidence, among which ischemic stroke met the diagnostic criteria of Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2018, and cerebral hemorrhage diseases met the diagnostic criteria of Chinese Guidelines for the Diagnosis and Treatment of Cerebral hemorrhage 2019; (2) There are symptoms related to cognitive dysfunction; Cognitive dysfunction was assessed by rehabilitation physicians. According to the MoCA evaluation standard,MoCA score ≤26 points; according to the MMSE evaluation standard, illiteracy score ≤17 points; primary school education level ≤20 points; secondary school education (including secondary school) level ≤22 points; college education (including junior college) level ≤23 points; (3)Age range 40-80 years old; (4) no obvious aphasia, speech expression and attention can cooperate with the completion of evaluation and treatment; (5)The patient or the patient's family members read and agree to sign the informed consent.
• Exclusion Criteria:
• • (1) Patients with severe diseases, such as malignant arrhythmia, acute myocardial infarction and acute heart failure, who cannot tolerate rehabilitation treatment; (2) Patients with untreated intracranial aneurysms, severe epilepsy, and intracranial metals who cannot receive tDCS treatment; (3) Non-PSCI patients with cognitive impairment, including patients with cognitive impairment left over from previous stroke and other organ disorders.